Federica Klaus studied medicine at the University of Zurich in Switzerland where she also received her M.D. and Ph.D. She conducted her MD-Thesis on genetic effects on sleep in humans and completed an MD-PhD program in neurosciences on the effect of inflammation in mouse models of depression. During her residency in psychiatry at the Psychiatric University Hospital of Zurich, she investigated the interplay between inflammation and apathy in depression and schizophrenia. She is currently a postdoctoral fellow funded by the SNSF (Swiss National Science Foundation) at the University of California, San Diego, USA, where she investigates the relationship between peripheral and brain inflammation using neuroimaging as pathomechanisms of negative symptoms in schizophrenia.
Her research interests are clinical investigations on mental illness and the relationship of objective measures with behavior and psychopathology in a transdiagnostic approach, with a current focus on the relationship between inflammation and negative symptoms.
Klaus F, et al. Negativsymptome der Schizophrenie - ein Überblick. Therapeutische Umschau 2018; 75: 51–56.
Klaus F, et al. Symptômes négatifs de la schizophrénie – état des lieux et implications pratiques. Revue Médicale Suisse 2018; 619: 1660–64.
Klaus F, et al. Differential effects of peripheral and brain tumor necrosis factor on inflammation, sickness, emotional behavior and memory in mice. Brain Behav Immun 2016; 58:310–326.
Habbas S, Santello M, Becker D, Stubbe H, Zappia G, Liaudet N, Klaus FR, et al. Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling. Cell 2015; 163:1730–1741.
Pietropaolo S, Sluyter F, Crusio WE (Eds.). Behavioral Genetics of the Mouse. Cambridge: Cambridge University Press; 2014.
Pryce CR, Klaus F. Translating the evidence for gene association with depression into mouse models of depression- relevant behavior: current limitations and future potential. Neurosci Biobehav Rev 2013; 37:1380–1402.
Bachmann V, Klaus F, et al. Functional ADA Polymorphism Increases Sleep Depth and Reduces Vigilant Attention in Humans. Cereb Cortex 2011; 22: 962–970.